Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice

The consequences of tetraploidy and aneuploidy.

Polyploidy, an increased number of chromosome sets, is a surprisingly common phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in specific tissues as part of terminal differentiation. Changes in ploidy can also result from pathophysiological events that are caused by viral-induced cell fusion or erroneous cell division. Tetraploidization can initiate chr...

Neuronal tetraploidy in Alzheimer and aging

Study the Effect of Silymarin and Vitamin C in Skin Aging Induced by UVB Rays on the Mice Skin Redox System

Background: Exposure of the skin against occupational hazards is growing every day. Many scientists are trying to identify aspects about the mechanisms of damages done to the skin by them. The skin is the second metabolism organ of the body where redox-dependent metabolic pathways overcome. By considering the UV index, Iranians are at high risk of UVB damage by generation of reactive oxygen spe...

Congestive heart failure in copper-deficient mice.

Copper Deficiency (CuD) leads to hypertrophic cardiomyopathy in various experimental models. The morphological, electrophysiological, and molecular aspects of this hypertrophy have been under investigation for a long time. However the transition from compensated hypertrophy to decompensated heart failure has not been investigated in the study of CuD. We set out to investigate the contractile an...

Modulatory role of nitric oxide releasing NSAIDs in aging- and lipopolysaccharide-induced cognitive dysfunction in mice

Inflammatory processes play a critical role in the pathogenesis of the neurodegenerative disorders and are associated with cognitive impairments. Nonsteroidal anti-inflammatory drugs (NSAIDs) and nitric oxide releasing NSAIDs are reported to be effective in reducing the risk of developing AD or cognitive impairments. Present experiments were performed to study the possible effect of nitro napro...